Astros vs. Angels Prediction: Houston Predicted to Win Friday's MLB Matchup [6/20/2025]

The Los Angeles Angels and Houston Astros will meet in MLB action at Angel Stadium on Friday, starting at 9:38PM ET.

The Angels will send Yusei Kikuchi (2-6, 3.05 ERA) to the mound, pitting him against Hunter Brown (8-3, 1.88 ERA) for the Astros.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Astros-Angels game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Astros' chance of winning is 58%, while the Angels' is 42%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Astros vs. Angels predictions page.

Angels vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Friday's MLB game between the Astros and Angels 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 58% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 55% chance of covering the run line, while the 8-run over/under has a 51% chance of going over.

Astros vs. Angels Odds [6/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Angels
Run Line	-1.5 (+102)	+1.5 (-120)
Moneyline	-166	+143
Total	o8 (-106)	u8 (-106)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Angels Picks and Best Bets

Our model's strongest edge in today's Astros vs. Angels matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Astros vs. Angels Game-Day Updates and Essential Details

Friday's MLB action between the Angels and Astros at Angel Stadium is scheduled to start at 9:38PM ET.

• Who: Houston Astros vs. Los Angeles Angels
• Date: Friday, June 20, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers.com's full preview of Friday's Astros vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Astros, with a 58% win probability, will likely beat the Angels on Friday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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