Astros vs. Tigers prediction: Houston predicted to win Wednesday's MLB matchup [8/20/2025]

MLB action continues on Wednesday at 1:10PM ET as the Houston Astros square off with the Detroit Tigers at Comerica Park.

Charlie Morton (8-10, 5.20 ERA) will start for the Tigers, up against Framber Valdez (11-6, 3.01 ERA) for the Astros.

Based on the latest simulation results, Dimers' advanced MLB model projects the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Astros-Tigers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 54%, with the Tigers at 46%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Tigers predictions page.

Tigers vs. Astros prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Astros and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 54% chance of beating the Tigers.

According to our model, the Tigers (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 53% chance of going over.

Astros vs. Tigers odds [8/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Tigers
Run Line	-1.5 (+150)	+1.5 (-175)
Moneyline	-114	-102
Total	o8 (-110)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Tigers picks and best bets

Our model's biggest edge in today's Astros vs. Tigers matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Astros vs. Tigers game-day updates and essential details

Wednesday's MLB matchup between the Tigers and Astros at Comerica Park is scheduled to start at 1:10PM ET.

• Who: Houston Astros vs. Detroit Tigers
• Date: Wednesday, August 20, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Wednesday's Astros vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 54% win probability, will likely beat the Tigers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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