Astros vs. Orioles prediction: Baltimore favored to win Thursday's MLB matchup [8/21/2025]

The Baltimore Orioles will take on the Houston Astros, in what is expected to be a tight MLB game, at Oriole Park at Camden Yards on Thursday, starting at 7:15PM ET.

Brandon Young (1-6, 5.68 ERA) will get the ball for the Orioles, pitting him against Jason Alexander (3-1, 4.74 ERA) for the Astros.

Based on updated simulations, Dimers' advanced MLB model projects the Orioles as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Astros vs. Orioles predictions page.

Orioles vs. Astros prediction: Who will win?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB matchup between the Astros and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Orioles a 52% chance of beating the Astros.

According to our model, the over/under total of 8.5 runs has a 54% chance of going over.

Astros vs. Orioles odds [8/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Orioles
Moneyline	+100	-118
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Orioles picks and best bets

Our model's biggest edge in today's Astros vs. Orioles matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

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Astros vs. Orioles game-day updates and essential details

Thursday's MLB action between the Orioles and Astros at Oriole Park at Camden Yards is scheduled to start at 7:15PM ET.

• Who: Houston Astros vs. Baltimore Orioles
• Date: Thursday, August 21, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's in-depth preview of Thursday's Astros vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Orioles, with a 52% win probability, will likely beat the Astros on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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