Astros vs. Orioles prediction: Houston favored to win Friday's MLB matchup [8/22/2025]

The Baltimore Orioles and Houston Astros are scheduled to meet in MLB action at Oriole Park at Camden Yards on Friday, starting at 7:05PM ET.

Cade Povich (2-6, 4.98 ERA) will be on the bump for the Orioles, while the Astros will counter with Lance McCullers (2-4, 6.90 ERA).

Based on updated simulation results, Dimers' advanced MLB model projects the Astros as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Astros vs. Orioles predictions page.

Orioles vs. Astros prediction: Who will win?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Astros and Orioles 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Astros a 52% chance of beating the Orioles.

According to our model, the over/under total of 9 runs has a 52% chance of going over.

Astros vs. Orioles odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Orioles
Moneyline	-110	-102
Total	o9 (-116)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Orioles picks and best bets

Our model's biggest edge in today's Astros vs. Orioles matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Astros vs. Orioles game-day updates and essential details

Friday's MLB game between the Orioles and Astros at Oriole Park at Camden Yards is scheduled to start at 7:05PM ET.

• Who: Houston Astros vs. Baltimore Orioles
• Date: Friday, August 22, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's full preview of Friday's Astros vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 52% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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