Astros vs. Diamondbacks Prediction: Arizona Predicted to Win Wednesday's MLB Matchup [7/23/2025]

The Arizona Diamondbacks will square off with the Houston Astros in MLB action at Chase Field on Wednesday, beginning at 3:40PM ET.

Brandon Pfaadt (10-6, 4.82 ERA) will get the ball for the Diamondbacks, up against Brandon Walter (1-3, 3.66 ERA) for the Astros.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Astros-Diamondbacks game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Diamondbacks' chance of winning at 56%, with the Astros at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Diamondbacks predictions page.

Diamondbacks vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Astros and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Diamondbacks a 56% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Astros vs. Diamondbacks Odds [7/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Diamondbacks
Run Line	+1.5 (-182)	-1.5 (+160)
Moneyline	+118	-131
Total	o8.5 (-108)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Astros vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Astros vs. Diamondbacks Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Diamondbacks and Astros at Chase Field is scheduled to start at 3:40PM ET.

• Who: Houston Astros vs. Arizona Diamondbacks
• Date: Wednesday, July 23, 2025
• Time: 3:40PM ET/12:40PM PT
• Venue: Chase Field

Dimers.com's full preview of Wednesday's Astros vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 56% win probability, will likely beat the Astros on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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