Astros vs. Diamondbacks Prediction: Close Contest Projected After New Data Released for Tuesday's MLB Matchup [7/22/2025]

MLB action continues on Tuesday at 9:40PM ET as the Houston Astros square off with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will have Eduardo Rodriguez (3-6, 5.94 ERA) as their starting pitcher, while the Astros have opted for Framber Valdez (10-4, 2.75 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects an equal chance for both the Diamondbacks and Astros to win today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Astros vs. Diamondbacks predictions page.

Diamondbacks vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB game between the Astros and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently can't split the two teams, giving both the Astros and Diamondbacks a 50% chance of winning the game.

According to our model, the Diamondbacks (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Astros vs. Diamondbacks Odds [7/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Diamondbacks
Run Line	-1.5 (+146)	+1.5 (-160)
Moneyline	-112	+100
Total	o8.5 (-102)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Diamondbacks Picks and Best Bets

Our model's strongest edge in today's Astros vs. Diamondbacks matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Astros vs. Diamondbacks Game-Day Updates and Essential Details

Tuesday's MLB game between the Diamondbacks and Astros at Chase Field is scheduled to begin at 9:40PM ET.

• Who: Houston Astros vs. Arizona Diamondbacks
• Date: Tuesday, July 22, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's in-depth preview of Tuesday's Astros vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Astros and Diamondbacks on Tuesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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