Holy Cross vs. Yale prediction: Yale favored to win in college football Week 4, 2025

Yale will take on Holy Cross in Week 4 college football action at Yale Bowl on Saturday, beginning at 12:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects Yale as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Holy Cross vs. Yale predictions page.

Holy Cross vs. Yale prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Holy Cross vs. Yale 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Yale a 64% chance of defeating Holy Cross. Our predicted final score has Yale winning 26-21.

According to our model, Holy Cross (+6.5) has a 55% chance of covering the spread, while the over/under total of 45.5 points has a 57% chance of staying under.

Holy Cross vs. Yale odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Holy Cross	Yale
Spread	+6.5 (-110)	-6.5 (-110)
Moneyline	+220	-205
Total	o45.5 (-110)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Holy Cross vs. Yale picks and best bets

Our model's biggest edge in today's Holy Cross vs. Yale matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Holy Cross vs. Yale game-day updates and essential details

Saturday's college football action between Yale and Holy Cross at Yale Bowl is scheduled to begin at 12:00PM ET.

• Who: Holy Cross vs. Yale
• Date: Saturday, September 20, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Yale Bowl

Dimers' in-depth preview of Saturday's Holy Cross vs. Yale matchup includes our prediction, picks and the latest betting odds.

Before making any Holy Cross vs. Yale picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Yale, with a 64% win probability, will likely beat Holy Cross on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Holy Cross vs. Yale insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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