Holy Cross vs. Northern Illinois prediction: Northern Illinois favored to win in college football Week 1, 2025

Northern Illinois will take on Holy Cross in college football action at Brigham Field at Huskie Stadium on Saturday, commencing at 3:30PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Northern Illinois as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Holy Cross vs. Northern Illinois predictions page.

Holy Cross vs. Northern Illinois prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Holy Cross vs. Northern Illinois 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Northern Illinois an 80% chance of defeating Holy Cross. Our predicted final score has Northern Illinois winning 30-18.

According to our model, Holy Cross (+13.5) has a 53% chance of covering the spread, while the 48.5-point over/under has a 55% chance of going over.

Holy Cross vs. Northern Illinois odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Holy Cross	Northern Illinois
Spread	+13.5 (-105)	-13.5 (-108)
Moneyline	+390	-500
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Holy Cross vs. Northern Illinois picks and best bets

Our model's biggest edge in today's Holy Cross vs. Northern Illinois matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Holy Cross vs. Northern Illinois game-day updates and essential details

Saturday's college football action between Northern Illinois and Holy Cross at Brigham Field at Huskie Stadium is scheduled to start at 3:30PM ET.

• Who: Holy Cross vs. Northern Illinois
• Date: Saturday, August 30, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Brigham Field at Huskie Stadium

Dimers.com's comprehensive preview of Saturday's Holy Cross vs. Northern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any Holy Cross vs. Northern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

Another way to make the most of Saturday's exciting day of sports, headlined by college football Saturday games, check out details on the latest Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Northern Illinois, with an 80% win probability, will likely beat Holy Cross on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Holy Cross vs. Northern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest predictions for the national title game and major conferences.