Grambling State vs. Ohio State prediction: Ohio State favored to win in college football Week 2, 2025

Ohio State will take on Grambling State in Week 2 college football action at Ohio Stadium on Saturday, starting at 3:30PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Ohio State as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Grambling State vs. Ohio State predictions page.

Grambling State vs. Ohio State prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of Grambling State vs. Ohio State 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Ohio State a 100% chance of beating Grambling State. Our predicted final score has Ohio State winning 61-4.

According to our model, the bookmakers have got it right, and Grambling State and Ohio State each have a 50% chance of covering the spread, while the 62.5-point over/under also has an equal 50-50 chance of hitting.

Grambling State vs. Ohio State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Grambling State	Ohio State
Spread	+55.5 (-105)	-55.5 (-110)
Moneyline	+8000	-100000
Total	o62.5 (-105)	u62.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Grambling State vs. Ohio State picks and best bets

Our model's strongest edge in today's Grambling State vs. Ohio State matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Grambling State vs. Ohio State game-day updates and essential details

Saturday's college football action between Ohio State and Grambling State at Ohio Stadium is scheduled to commence at 3:30PM ET.

• Who: Grambling State vs. Ohio State
• Date: Saturday, September 6, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Ohio Stadium

Dimers.com's full preview of Saturday's Grambling State vs. Ohio State matchup includes our prediction, picks and the latest betting odds.

Before making any Grambling State vs. Ohio State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Ohio State, with a 100% win probability, will likely beat Grambling State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Grambling State vs. Ohio State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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