Georgia Southern vs. Southern California prediction: Southern California favored to win in college football Week 2, 2025

Southern California will square off with Georgia Southern in Week 2 college football action at Los Angeles Memorial Coliseum on Saturday, beginning at 7:30PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Southern California as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Georgia Southern vs. Southern California predictions page.

Georgia Southern vs. Southern California prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the outcome of Georgia Southern vs. Southern California 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Southern California an 88% chance of beating Georgia Southern. Our predicted final score has Southern California winning 44-21.

According to our model, Southern California (-26.5) has a 54% chance of covering the spread, while the 60.5-point over/under has a 62% chance of going over.

Georgia Southern vs. Southern California odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Georgia Southern	Southern California
Spread	+26.5 (-120)	-26.5 (-110)
Moneyline	+2200	-2800
Total	o60.5 (-115)	u60.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Georgia Southern vs. Southern California picks and best bets

Our model's strongest edge in today's Georgia Southern vs. Southern California matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Georgia Southern vs. Southern California game-day updates and essential details

Saturday's college football game between Southern California and Georgia Southern at Los Angeles Memorial Coliseum is scheduled to commence at 7:30PM ET.

• Who: Georgia Southern vs. Southern California
• Date: Saturday, September 6, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Los Angeles Memorial Coliseum

Dimers.com's full preview of Saturday's Georgia Southern vs. Southern California matchup includes our prediction, picks and the latest betting odds.

Before making any Georgia Southern vs. Southern California picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's massive day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that grants you $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Southern California, with an 88% win probability, will likely beat Georgia Southern on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Georgia Southern vs. Southern California insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Football

Stay informed with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the latest projections for the national title game and major conferences.