Frances Tiafoe vs. Holger Rune Prediction, Odds, Picks for ATP Cincinnati Open 2025

Frances Tiafoe will square off with Holger Rune in the round of 16 at the ATP Cincinnati event on Wednesday.

Based on the latest simulations, Dimers' proven tennis model (see Dimers Pro for full access) predicts Frances Tiafoe as the most likely winner of the match. "We have simulated the outcome of Wednesday's Tiafoe-Rune match 10,000 times," said Dimers data analyst Greg Butyn.

"With the latest updates and numerous other variables, we estimate Frances Tiafoe's chance of winning at 51%, with Holger Rune at 49%."

For a closer look at Wednesday's match, including best bets and picks, visit our interactive Tiafoe vs. Rune predictions page.

Tiafoe vs. Rune Prediction: Who Will Win and Advance to the Quarterfinals?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's Tiafoe-Rune men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model currently gives Tiafoe a 51% chance of winning against Rune at the ATP Cincinnati Open tournament.

Additionally, Tiafoe has a 51% chance of winning the first set, according to our model.

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Frances Tiafoe vs. Holger Rune Odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Tiafoe	Rune
Moneyline	+110	-139
First Set	+100	-125

All odds are correct at the time of publication and are subject to change.

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Tiafoe vs. Rune Picks and Best Bets

Our model's biggest edge in today's Tiafoe vs. Rune match is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Tiafoe vs. Rune Updates and Essential Details

The ATP Cincinnati Open match between Frances Tiafoe and Holger Rune is scheduled to start on Wednesday at 11:00AM ET.

• Who: Frances Tiafoe vs. Holger Rune
• Date: Wednesday, August 13, 2025
• Approx. Time: 11:00AM ET/8:00AM PT
• Tournament: ATP Cincinnati, USA Men's Singles 2025
• Round: Round of 16

All dates and times mentioned in this article are United States Eastern Time unless otherwise noted.

Dimers.com's full preview of Wednesday's Tiafoe vs. Rune match includes our prediction, picks and the latest betting odds.

Before making any Frances Tiafoe vs. Holger Rune picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

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Conclusion

We predict Frances Tiafoe, with a 51% win probability, will likely beat Holger Rune at the ATP Cincinnati Open tournament.

AI and automation have enhanced this article to quickly deliver accurate Tiafoe vs. Rune insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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