Florida vs. LSU prediction: LSU favored to win in college football Week 3, 2025

LSU and Florida will lock horns in Week 3 college football action at Tiger Stadium on Saturday, with kickoff at 7:30PM ET.

Based on updated simulation results, Dimers' proven college football model projects LSU as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Florida vs. LSU predictions page.

Florida vs. LSU prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Florida vs. LSU 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives LSU a 63% chance of beating Florida. Our predicted final score has LSU winning 26-21.

According to our model, the bookmakers have got it right, and Florida and LSU each have a 50% chance of covering the spread, while the over/under total of 47.5 points has a 53% chance of staying under.

Florida vs. LSU odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Florida	LSU
Spread	+4.5 (+100)	-4.5 (-110)
Moneyline	+190	-220
Total	o47.5 (-105)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Florida vs. LSU picks and best bets

Our model's strongest edge in today's Florida vs. LSU matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Florida vs. LSU game-day updates and essential details

Saturday's college football action between LSU and Florida at Tiger Stadium is scheduled to begin at 7:30PM ET.

• Who: Florida vs. LSU
• Date: Saturday, September 13, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Tiger Stadium

Dimers' full preview of Saturday's Florida vs. LSU matchup includes our prediction, picks and the latest betting odds.

Before making any Florida vs. LSU picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict LSU, with a 63% win probability, will likely beat Florida on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Florida vs. LSU insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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