Eastern Kentucky vs. Louisville prediction: Louisville favored to win in college football Week 1, 2025

Louisville and Eastern Kentucky will meet in college football action at L&N Federal Credit Union Stadium on Saturday, with kickoff at 3:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Louisville as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Eastern Kentucky vs. Louisville predictions page.

Eastern Kentucky vs. Louisville prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Eastern Kentucky vs. Louisville 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Louisville a 99% chance of defeating Eastern Kentucky. Our predicted final score has Louisville winning 45-8.

According to our model, the bookmakers have got it right, and Eastern Kentucky and Louisville each have a 50% chance of covering the spread, while the 56.5-point over/under has a 56% chance of going over.

Eastern Kentucky vs. Louisville odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	Eastern Kentucky	Louisville
Spread	+38.5 (-110)	-38.5 (-108)
Moneyline	+8000	-100000
Total	o56.5 (-108)	u56.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Eastern Kentucky vs. Louisville picks and best bets

Our model's biggest edge in today's Eastern Kentucky vs. Louisville matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Eastern Kentucky vs. Louisville game-day updates and essential details

Saturday's college football game between Louisville and Eastern Kentucky at L&N Federal Credit Union Stadium is scheduled to begin at 3:00PM ET.

• Who: Eastern Kentucky vs. Louisville
• Date: Saturday, August 30, 2025
• Time: 3:00PM ET/12:00PM PT
• Venue: L&N Federal Credit Union Stadium

Dimers.com's full preview of Saturday's Eastern Kentucky vs. Louisville matchup includes our prediction, picks and the latest betting odds.

Before making any Eastern Kentucky vs. Louisville picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Louisville, with a 99% win probability, will likely beat Eastern Kentucky on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Eastern Kentucky vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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