Eastern Illinois vs. Indiana State prediction: Why Indiana State is favored to win in college football Week 2, 2025

Indiana State will face Eastern Illinois in Week 2 college football action at Memorial Stadium on Saturday, with kickoff at 1:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Indiana State as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Eastern Illinois vs. Indiana State predictions page.

Eastern Illinois vs. Indiana State prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Eastern Illinois vs. Indiana State 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Indiana State a 54% chance of defeating Eastern Illinois. Our predicted final score has Indiana State winning 26-25.

According to our model, Eastern Illinois (+4) has a 61% chance of covering the spread, while the 50.5-point over/under has a 53% chance of staying under.

Eastern Illinois vs. Indiana State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Eastern Illinois	Indiana State
Spread	+4 (-110)	-4 (-110)
Moneyline	+150	-155
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Eastern Illinois vs. Indiana State picks and best bets

Our model's strongest edge in today's Eastern Illinois vs. Indiana State matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Eastern Illinois vs. Indiana State game-day updates and essential details

Saturday's college football action between Indiana State and Eastern Illinois at Memorial Stadium is scheduled to start at 1:00PM ET.

• Who: Eastern Illinois vs. Indiana State
• Date: Saturday, September 6, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Memorial Stadium

Dimers.com's full preview of Saturday's Eastern Illinois vs. Indiana State matchup includes our prediction, picks and the latest betting odds.

Before making any Eastern Illinois vs. Indiana State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's mammoth day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that secures $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Indiana State, with a 54% win probability, will likely beat Eastern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Eastern Illinois vs. Indiana State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on College Football

Stay up-to-date with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most up-to-date probabilities for the national title game and major conferences.