East Tennessee State vs. Tennessee prediction: Why Tennessee is favored to win in college football Week 2, 2025

Tennessee and East Tennessee State will clash in Week 2 college football action at Neyland Stadium on Saturday, commencing at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Tennessee as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive East Tennessee State vs. Tennessee predictions page.

East Tennessee State vs. Tennessee prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of East Tennessee State vs. Tennessee 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Tennessee a 99% chance of beating East Tennessee State. Our predicted final score has Tennessee winning 47-8.

According to our model, the bookies have got it right, and East Tennessee State and Tennessee each have a 50% chance of covering the spread, while the 58.5-point over/under has a 64% chance of going over.

East Tennessee State vs. Tennessee odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	East Tennessee State	Tennessee
Spread	+40.5 (-110)	-40.5 (-110)
Moneyline	+8000	-100000
Total	o58.5 (-115)	u58.5 (+100)

All odds are correct at the time of publication and are subject to change.

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East Tennessee State vs. Tennessee picks and best bets

Our model's biggest edge in today's East Tennessee State vs. Tennessee matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

East Tennessee State vs. Tennessee game-day updates and essential details

Saturday's college football game between Tennessee and East Tennessee State at Neyland Stadium is scheduled to start at 3:30PM ET.

• Who: East Tennessee State vs. Tennessee
• Date: Saturday, September 6, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Neyland Stadium

Dimers.com's full preview of Saturday's East Tennessee State vs. Tennessee matchup includes our prediction, picks and the latest betting odds.

Before making any East Tennessee State vs. Tennessee picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Tennessee, with a 99% win probability, will likely beat East Tennessee State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate East Tennessee State vs. Tennessee insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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