Duquesne vs. Pittsburgh prediction: Why Pittsburgh is favored to win in college football Week 1, 2025

Pittsburgh will square off with Duquesne in college football action at Acrisure Stadium on Saturday, beginning at 12:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects Pittsburgh as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Duquesne vs. Pittsburgh predictions page.

Duquesne vs. Pittsburgh prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the outcome of Duquesne vs. Pittsburgh 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Pittsburgh a 99% chance of beating Duquesne. Our predicted final score has Pittsburgh winning 47-8.

According to our model, the bookmakers have got it right, and Duquesne and Pittsburgh each have a 50% chance of covering the spread, while the over/under total of 57.5 points has a 54% chance of going over.

Duquesne vs. Pittsburgh odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Duquesne	Pittsburgh
Spread	+39.5 (-108)	-39.5 (-102)
Moneyline	+8000	-100000
Total	o57.5 (-110)	u57.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Duquesne vs. Pittsburgh picks and best bets

Our model's biggest edge in today's Duquesne vs. Pittsburgh matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Duquesne vs. Pittsburgh game-day updates and essential details

Saturday's college football matchup between Pittsburgh and Duquesne at Acrisure Stadium is scheduled to start at 12:00PM ET.

• Who: Duquesne vs. Pittsburgh
• Date: Saturday, August 30, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Acrisure Stadium

Dimers.com's comprehensive preview of Saturday's Duquesne vs. Pittsburgh matchup includes our prediction, picks and the latest betting odds.

Before making any Duquesne vs. Pittsburgh picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Pittsburgh, with a 99% win probability, will likely beat Duquesne on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Duquesne vs. Pittsburgh insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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