Duke vs. Tulane prediction: Why Tulane is favored to win in college football Week 3, 2025

Tulane and Duke will meet in Week 3 college football action at Yulman Stadium on Saturday, commencing at 8:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts Tulane as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Duke vs. Tulane predictions page.

Duke vs. Tulane prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the result of Duke vs. Tulane 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Tulane a 54% chance of defeating Duke. Our predicted final score has Tulane winning 27-25.

According to our model, the bookmakers have got it right, and Duke and Tulane each have a 50% chance of covering the spread, while the over/under total of 52.5 points has a 52% chance of staying under.

Duke vs. Tulane odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Duke	Tulane
Spread	+1.5 (-110)	-1.5 (-105)
Moneyline	+100	-114
Total	o52.5 (-108)	u52.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Duke vs. Tulane picks and best bets

Our model's strongest edge in today's Duke vs. Tulane matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Duke vs. Tulane game-day updates and essential details

Saturday's college football action between Tulane and Duke at Yulman Stadium is scheduled to begin at 8:00PM ET.

• Who: Duke vs. Tulane
• Date: Saturday, September 13, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Yulman Stadium

Dimers' in-depth preview of Saturday's Duke vs. Tulane matchup includes our prediction, picks and the latest betting odds.

Before making any Duke vs. Tulane picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Tulane, with a 54% win probability, will likely beat Duke on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Duke vs. Tulane insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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