Duke vs. Syracuse prediction: Duke favored to win in college football Week 5, 2025

Syracuse and Duke will meet in Week 5 college football action at JMA Wireless Dome on Saturday, commencing at 12:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Duke as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Duke vs. Syracuse predictions page.

Duke vs. Syracuse prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Duke vs. Syracuse 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Duke a 51% chance of beating Syracuse. Our predicted score is Duke 30-30 Syracuse.

According to our model, Syracuse (+5.5) has a 64% chance of covering the spread, while the over/under total of 59.5 points has a 52% chance of staying under.

While there is no way for a College Football game to end in a tie, our prediction of 30-30 is based on each team's average score in the above-mentioned simulations of Duke vs. Syracuse.

Duke vs. Syracuse odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Duke	Syracuse
Spread	-5.5 (+100)	+5.5 (-120)
Moneyline	-178	+170
Total	o59.5 (-105)	u59.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Duke vs. Syracuse picks and best bets

Our model's biggest edge in today's Duke vs. Syracuse matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Duke vs. Syracuse game-day updates and essential details

Saturday's college football game between Syracuse and Duke at JMA Wireless Dome is scheduled to start at 12:00PM ET.

• Who: Duke vs. Syracuse
• Date: Saturday, September 27, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: JMA Wireless Dome

Dimers' in-depth preview of Saturday's Duke vs. Syracuse matchup includes our prediction, picks and the latest betting odds.

Before making any Duke vs. Syracuse picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Duke, with a 51% win probability, will likely beat Syracuse on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Duke vs. Syracuse insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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