Drake vs. South Dakota prediction: South Dakota favored to win in college football Week 4, 2025

South Dakota will take on Drake in Week 4 college football action at The DakotaDome on Saturday, with kickoff at 2:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts South Dakota as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Drake vs. South Dakota predictions page.

Drake vs. South Dakota prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the result of Drake vs. South Dakota 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives South Dakota an 89% chance of defeating Drake. Our predicted final score has South Dakota winning 31-14.

According to our model, Drake (+17.5) has a 54% chance of covering the spread, while the 45.5-point over/under has a 52% chance of going over.

Drake vs. South Dakota odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Drake	South Dakota
Spread	+17.5 (-110)	-17.5 (-110)
Moneyline	+600	-820
Total	o45.5 (-112)	u45.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Drake vs. South Dakota picks and best bets

Our model's biggest edge in today's Drake vs. South Dakota matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Drake vs. South Dakota game-day updates and essential details

Saturday's college football game between South Dakota and Drake at The DakotaDome is scheduled to start at 2:00PM ET.

• Who: Drake vs. South Dakota
• Date: Saturday, September 20, 2025
• Time: 2:00PM ET/11:00AM PT
• Venue: The DakotaDome

Dimers' comprehensive preview of Saturday's Drake vs. South Dakota matchup includes our prediction, picks and the latest betting odds.

Before making any Drake vs. South Dakota picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict South Dakota, with an 89% win probability, will likely beat Drake on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Drake vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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