Tigers vs. Cardinals Prediction: St. Louis Predicted to Win Wednesday's MLB Matchup [5/21/2025]

The St. Louis Cardinals will take on the Detroit Tigers in MLB action at Busch Stadium on Wednesday, starting at 1:15PM ET.

Andre Pallante (4-2, 4.11 ERA) will get the ball for the Cardinals, up against Brant Hurter (1-0, 2.35 ERA) for the Tigers.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Detroit-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 53%, with the Tigers at 47%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Tigers vs. Cardinals predictions page.

Cardinals vs. Tigers Prediction: Who Will Win?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Tigers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 53% chance of defeating the Tigers.

According to our model, the 9-run over/under has a 54% chance of staying under.

Tigers vs. Cardinals Odds [5/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Cardinals
Moneyline	-102	-115
Total	o9 (+100)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Tigers vs. Cardinals matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Tigers vs. Cardinals Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Cardinals and Tigers at Busch Stadium is scheduled to start at 1:15PM ET.

• Who: Detroit Tigers vs. St. Louis Cardinals
• Date: Wednesday, May 21, 2025
• Time: 1:15PM ET/10:15AM PT
• Venue: Busch Stadium

Dimers.com's full preview of Wednesday's Tigers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Detroit vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 53% win probability, will likely beat the Tigers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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