Tigers vs. Cardinals Prediction: Detroit Predicted to Win Tuesday's MLB Matchup [5/20/2025]

The St. Louis Cardinals will face the Detroit Tigers in MLB action at Busch Stadium on Tuesday, beginning at 7:45PM ET.

The Cardinals will start Erick Fedde (3-3, 3.44 ERA), pitting him against Tarik Skubal (4-2, 2.67 ERA) for the Tigers.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Tigers as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Detroit-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Tigers with a win probability of 59%, compared to 41% for the Cardinals."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Tigers vs. Cardinals predictions page.

Cardinals vs. Tigers Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's MLB matchup between the Tigers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Tigers a 59% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 55% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of staying under.

Tigers vs. Cardinals Odds [5/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Cardinals
Run Line	-1.5 (-102)	+1.5 (-114)
Moneyline	-176	+150
Total	o7.5 (-105)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Tigers vs. Cardinals matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Tigers vs. Cardinals Game-Day Updates and Essential Details

Tuesday's MLB action between the Cardinals and Tigers at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Detroit Tigers vs. St. Louis Cardinals
• Date: Tuesday, May 20, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Tuesday's Tigers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Detroit vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Tigers, with a 59% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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