Tigers vs. Cardinals Prediction: St. Louis Predicted to Win Monday's MLB Matchup [5/19/2025]

The St. Louis Cardinals and Detroit Tigers will lock horns in MLB action at Busch Stadium on Monday, starting at 7:45PM ET.

The Cardinals will start Sonny Gray (4-1, 4.50 ERA), while the Tigers are going with Sean Guenther (0-0, 2.25 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Detroit-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Cardinals are likely to win, with a probability of 60%, compared to the Tigers' 40%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Tigers vs. Cardinals predictions page.

Cardinals vs. Tigers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Tigers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 60% chance of defeating the Tigers.

According to our model, the Tigers (+1.5) have a 59% chance of covering the run line, while the 8-run over/under has a 52% chance of staying under.

Tigers vs. Cardinals Odds [5/19/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Cardinals
Run Line	+1.5 (-152)	-1.5 (+136)
Moneyline	+140	-165
Total	o8 (-105)	u8 (-115)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Tigers vs. Cardinals matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Tigers vs. Cardinals Game-Day Updates and Essential Details

Monday's MLB action between the Cardinals and Tigers at Busch Stadium is scheduled to commence at 7:45PM ET.

• Who: Detroit Tigers vs. St. Louis Cardinals
• Date: Monday, May 19, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Monday's Tigers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Detroit vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cardinals, with a 60% win probability, will likely beat the Tigers on Monday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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