Tigers vs. Pirates Prediction: Detroit Predicted to Win Tuesday's MLB Matchup [7/22/2025]

The Pittsburgh Pirates will take on the Detroit Tigers, in what is expected to be a close MLB game, at PNC Park on Tuesday, beginning at 6:40PM ET.

Mitch Keller (3-10, 3.48 ERA) will be on the bump for the Pirates, while the Tigers will counter with Casey Mize (9-3, 3.15 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Tigers vs. Pirates predictions page.

Pirates vs. Tigers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the Tigers and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Tigers a 52% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 61% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of going over.

Tigers vs. Pirates Odds [7/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Pirates
Run Line	-1.5 (+129)	+1.5 (-150)
Moneyline	-134	+115
Total	o8 (-110)	u8 (-106)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Tigers vs. Pirates matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Tigers vs. Pirates Game-Day Updates and Essential Details

Tuesday's MLB action between the Pirates and Tigers at PNC Park is scheduled to start at 6:40PM ET.

• Who: Detroit Tigers vs. Pittsburgh Pirates
• Date: Tuesday, July 22, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Tuesday's Tigers vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Tigers, with a 52% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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