Tigers vs. Pirates Prediction: Pittsburgh Predicted to Win Monday's MLB Matchup [7/21/2025]

The Pittsburgh Pirates will face the Detroit Tigers in MLB action at PNC Park on Monday, beginning at 6:40PM ET.

The Pirates will have Paul Skenes (4-8, 2.01 ERA) as their starting pitcher, while the Tigers have opted for Jack Flaherty (5-9, 4.65 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Pirates as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Tigers vs. Pirates predictions page.

Pirates vs. Tigers Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Monday's MLB game between the Tigers and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Pirates a 55% chance of beating the Tigers.

According to our model, the Tigers (+1.5) have a 65% chance of covering the run line, while the 7-run over/under has a 51% chance of going over.

Tigers vs. Pirates Odds [7/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Pirates
Run Line	+1.5 (-208)	-1.5 (+180)
Moneyline	+108	-125
Total	o7 (-120)	u7 (+101)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Tigers vs. Pirates matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Tigers vs. Pirates Game-Day Updates and Essential Details

Monday's MLB matchup between the Pirates and Tigers at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Detroit Tigers vs. Pittsburgh Pirates
• Date: Monday, July 21, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Monday's Tigers vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Pirates, with a 55% win probability, will likely beat the Tigers on Monday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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