Tigers vs. Guardians prediction: Why Cleveland is favored to win Wednesday's MLB matchup [9/24/2025]

The Cleveland Guardians will take on the Detroit Tigers in MLB action at Progressive Field on Wednesday, commencing at 6:40PM ET.

The Guardians will send Tanner Bibee (11-11, 4.34 ERA) to the mound, up against Jack Flaherty (8-14, 4.60 ERA) for the Tigers.

Based on updated simulations, Dimers' advanced MLB model predicts the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Tigers-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 56%, with the Tigers at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Tigers vs. Guardians predictions page.

Guardians vs. Tigers prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Tigers and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 56% chance of defeating the Tigers.

According to our model, the Tigers (+1.5) have a 63% chance of covering the run line, while the 7.5-run over/under has a 59% chance of going over.

Tigers vs. Guardians odds [9/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Guardians
Run Line	+1.5 (-176)	-1.5 (+152)
Moneyline	+125	-142
Total	o7.5 (-115)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Guardians picks and best bets

Our model's biggest edge in today's Tigers vs. Guardians matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Tigers vs. Guardians game-day updates and essential details

Wednesday's MLB game between the Guardians and Tigers at Progressive Field is scheduled to start at 6:40PM ET.

• Who: Detroit Tigers vs. Cleveland Guardians
• Date: Wednesday, September 24, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers' full preview of Wednesday's Tigers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 56% win probability, will likely beat the Tigers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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