Tigers vs. Guardians prediction: Cy Young candidate Tarik Skubal takes on Cleveland tonight [9/23/2025]

MLB action continues on Tuesday at 6:40PM ET as the Detroit Tigers square off with the Cleveland Guardians at Progressive Field.

Gavin Williams (11-5, 3.06 ERA) will be on the bump for the Guardians, up against Cy Young hopeful Tarik Skubal (13-5, 2.23 ERA) for the Tigers.

Based on updated simulation results, Dimers' advanced MLB model predicts the Tigers as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Tigers vs. Guardians predictions page.

Guardians vs. Tigers prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Tuesday's MLB game between the Tigers and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Tigers a 59% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 56% chance of covering the run line, while the over/under total of 6.5 runs has a 60% chance of going over.

Tigers vs. Guardians odds [9/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Guardians
Run Line	-1.5 (+118)	+1.5 (-137)
Moneyline	-158	+137
Total	o6.5 (-115)	u6.5 (+102)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Guardians picks and best bets

Our model's biggest edge in today's Tigers vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Tigers vs. Guardians game-day updates and essential details

Tuesday's MLB action between the Guardians and Tigers at Progressive Field is scheduled to commence at 6:40PM ET.

• Who: Detroit Tigers vs. Cleveland Guardians
• Date: Tuesday, September 23, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers' comprehensive preview of Tuesday's Tigers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Tigers, with a 59% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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