Tigers vs. Guardians prediction: Why Cleveland is favored to win Thursday's MLB matchup [9/25/2025]

The Cleveland Guardians will face the Detroit Tigers in MLB action at Progressive Field on Thursday, starting at 6:40PM ET.

Parker Messick (3-0, 2.08 ERA) will start for the Guardians, while the Tigers have opted for Troy Melton (3-2, 2.79 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Guardians as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Tigers vs. Guardians predictions page.

Guardians vs. Tigers prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Tigers and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Guardians a 59% chance of beating the Tigers.

According to our model, the Tigers (+1.5) have a 60% chance of covering the run line, while the 7.5-run over/under has a 57% chance of going over.

Tigers vs. Guardians odds [9/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Guardians
Run Line	+1.5 (-160)	-1.5 (+140)
Moneyline	+140	-158
Total	o7.5 (-105)	u7.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Guardians picks and best bets

Our model's biggest edge in today's Tigers vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Tigers vs. Guardians game-day updates and essential details

Thursday's MLB matchup between the Guardians and Tigers at Progressive Field is scheduled to commence at 6:40PM ET.

• Who: Detroit Tigers vs. Cleveland Guardians
• Date: Thursday, September 25, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers' full preview of Thursday's Tigers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 59% win probability, will likely beat the Tigers on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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