Tigers vs. White Sox Prediction: Detroit Predicted to Win Wednesday's MLB Matchup [6/4/2025]

The Chicago White Sox and Detroit Tigers will meet in MLB action at Rate Field on Wednesday, starting at 7:40PM ET.

Jared Shuster (0-0, 6.14 ERA) will start on the mound for the White Sox, up against Sawyer Gipson-Long (0-0, 0.00 ERA) for the Tigers.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Tigers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Detroit-CHI White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Tigers' chance of winning at 62%, with the White Sox at 38%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Tigers vs. White Sox predictions page.

White Sox vs. Tigers Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Tigers and White Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Tigers a 62% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 52% chance of covering the run line, while the 8-run over/under has an equal 50-50 chance of hitting.

Tigers vs. White Sox Odds [6/4/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	White Sox
Run Line	-1.5 (-113)	+1.5 (+102)
Moneyline	-198	+168
Total	o8 (-102)	u8 (-115)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Tigers vs. White Sox matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Tigers vs. White Sox Game-Day Updates and Essential Details

Wednesday's MLB game between the White Sox and Tigers at Rate Field is scheduled to commence at 7:40PM ET.

• Who: Detroit Tigers vs. Chicago White Sox
• Date: Wednesday, June 4, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's full preview of Wednesday's Tigers vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Detroit vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Tigers, with a 62% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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