Tigers vs. Red Sox prediction: Boston favored to win Sunday's MLB matchup [9/28/2025]

MLB action continues on Sunday at 3:05PM ET as the Detroit Tigers take on the Boston Red Sox at Fenway Park.

José De León (0-0, 0.00 ERA) will be on the bump for the Red Sox, up against Chris Paddack (5-11, 5.27 ERA) for the Tigers.

Based on the latest simulations, Dimers' proven MLB model predicts the Red Sox as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Tigers-Red Sox game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Red Sox with a win probability of 53%, while the Tigers have 47%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Tigers vs. Red Sox predictions page.

Red Sox vs. Tigers prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the result of Sunday's MLB matchup between the Tigers and Red Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Red Sox a 53% chance of defeating the Tigers.

According to our model, the Red Sox (+1.5) have a 63% chance of covering the run line, while the 9-run over/under has a 65% chance of going over.

Tigers vs. Red Sox odds [9/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Red Sox
Run Line	-1.5 (+145)	+1.5 (-168)
Moneyline	-110	-104
Total	o9 (-115)	u9 (+102)

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Red Sox picks and best bets

Our model's strongest edge in today's Tigers vs. Red Sox matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Tigers vs. Red Sox game-day updates and essential details

Sunday's MLB game between the Red Sox and Tigers at Fenway Park is scheduled to commence at 3:05PM ET.

• Who: Detroit Tigers vs. Boston Red Sox
• Date: Sunday, September 28, 2025
• Time: 3:05PM ET/12:05PM PT
• Venue: Fenway Park

Dimers' comprehensive preview of Sunday's Tigers vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Red Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Red Sox, with a 53% win probability, will likely beat the Tigers on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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