Tigers vs. Red Sox prediction: Boston favored to win Friday's MLB matchup [9/26/2025]

The Boston Red Sox and Detroit Tigers are scheduled to meet in MLB action at Fenway Park on Friday, starting at 7:10PM ET.

The Red Sox will start Kyle Harrison (1-1, 3.58 ERA), up against Casey Mize (14-6, 3.91 ERA) for the Tigers.

Based on the latest simulations, Dimers' advanced MLB model predicts the Red Sox as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Tigers vs. Red Sox predictions page.

Red Sox vs. Tigers prediction: Who will win?

Using powerful machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Tigers and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Red Sox a 55% chance of defeating the Tigers.

According to our model, the 9-run over/under has a 56% chance of going over.

Tigers vs. Red Sox odds [9/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Tigers	Red Sox
Moneyline	+102	-120
Total	o9 (-105)	u9 (-112)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Tigers vs. Red Sox picks and best bets

Our model's strongest edge in today's Tigers vs. Red Sox matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Tigers vs. Red Sox game-day updates and essential details

Friday's MLB game between the Red Sox and Tigers at Fenway Park is scheduled to start at 7:10PM ET.

• Who: Detroit Tigers vs. Boston Red Sox
• Date: Friday, September 26, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Fenway Park

Dimers' comprehensive preview of Friday's Tigers vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Red Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Red Sox, with a 55% win probability, will likely beat the Tigers on Friday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.