Detroit Lions vs. Green Bay Packers early prediction: Expert picks for NFL Week 1, 2025

The Detroit Lions and Green Bay Packers will meet in Week 1 of the NFL season at Lambeau Field on Sunday, September 7, 2025, starting at 4:25PM ET.

Initial simulations from Dimers' trusted NFL model favor the Packers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Lions vs. Packers predictions page.

Detroit vs. Green Bay early predictions

Leveraging trusted machine learning and analysis, we have simulated the Lions vs. Packers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Lions 42%, Packers 58%
• Predicted final score: Lions 22-25 Packers
• Spread: Lions (+2.5) 50%, Packers (-2.5) 50%
• Total points (47.5): Over 50%, Under 50%

As of August 31, 2025, these Lions-Packers numbers and predictions reflect the latest data and insights available.

Lions vs. Packers Week 1 details

The NFL Week 1 game between the Packers and Lions at Lambeau Field is scheduled for September 7, 2025.

• Who: Detroit Lions vs. Green Bay Packers
• Date: Sunday, September 7, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Lambeau Field

Lions vs. Packers opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Lions +2.5 (-105), Packers -2.5 (-110)
• Moneyline: Lions +120, Packers -140
• Total: Over/Under 47.5 (-102/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Packers, with a 58% win probability, will likely beat the Lions in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Lions vs. Packers game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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