Detroit Lions vs. Cincinnati Bengals early prediction: Expert picks for NFL Week 5, 2025

The Detroit Lions and Cincinnati Bengals will meet in Week 5 of the NFL season at Paycor Stadium on Sunday, October 5, 2025, starting at 4:25PM ET.

Initial simulations from Dimers' trusted NFL model favor the Lions as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Lions vs. Bengals predictions page.

Detroit vs. Cincinnati early predictions

Leveraging trusted machine learning and analysis, we have simulated the Lions vs. Bengals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Lions 56%, Bengals 44%
• Predicted final score: Lions 25-24 Bengals
• Spread: Lions (-1.5) 50%, Bengals (+1.5) 50%
• Total points (50.5): Over 47%, Under 53%

As of September 28, 2025, these Lions-Bengals numbers and predictions reflect the latest data and insights available.

Lions vs. Bengals Week 5 details

The NFL Week 5 game between the Bengals and Lions at Paycor Stadium is scheduled for October 5, 2025.

• Who: Detroit Lions vs. Cincinnati Bengals
• Date: Sunday, October 5, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Paycor Stadium

Lions vs. Bengals opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Lions -1.5 (-105), Bengals +1.5 (-115)
• Moneyline: Lions -122, Bengals +102
• Total: Over/Under 50.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Lions, with a 56% win probability, will likely beat the Bengals in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Lions vs. Bengals matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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