DePaul vs. Creighton Prediction: Creighton Predicted to Win College Basketball Matchup [2/26/2025]

Creighton will square off with DePaul in college basketball action at CHI Health Center Omaha on Wednesday, commencing at 9:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model (see Dimers Pro for full access) projects Creighton as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has simulated the outcome of Wednesday's DePaul-Creighton game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate Creighton's chance of winning at 92%, with DePaul at 8%."

For expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive DePaul vs. Creighton predictions page.

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DePaul vs. Creighton Prediction: Who Will Win, Cover the Spread?

Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball game between DePaul and Creighton 10,000 times as part of our college basketball predictions coverage.

Our independent predictive model currently gives Creighton a 92% chance of beating DePaul. Our predicted final score has Creighton winning 82-66.

According to our model, the bookmakers have got it right, and DePaul and Creighton each have a 50% chance of covering the spread, while the over/under total of 147.5 points has a 54% chance of going over.

DePaul vs. Creighton Odds

We have sourced the best College Basketball odds in America for this game, which are listed here:

Bet Type	DePaul	Creighton
Spread	+15.5 (-102)	-15.5 (-114)
Moneyline	+1000	-1600
Total	o147.5 (-106)	u147.5 (-114)

All odds are correct at the time of publication and are subject to change.

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DePaul vs. Creighton Picks and Best Bets

Our model's strongest edge in today's DePaul vs. Creighton matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

DePaul vs. Creighton Game-Day Updates and Essential Details

Wednesday's college basketball game between Creighton and DePaul at CHI Health Center Omaha is scheduled to begin at 9:00PM ET.

• Who: DePaul vs. Creighton
• Date: Wednesday, February 26, 2025
• Time: 9:00PM ET/6:00PM PT
• Venue: CHI Health Center Omaha

Dimers.com's comprehensive preview of Wednesday's DePaul vs. Creighton matchup includes our prediction, picks and the latest betting odds.

Before making any DePaul vs. Creighton picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Creighton, with a 92% win probability, will likely beat DePaul on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate DePaul vs. Creighton insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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