Denver Broncos vs. Philadelphia Eagles early prediction: Expert picks for NFL Week 5, 2025

The Denver Broncos and Philadelphia Eagles will meet in Week 5 of the NFL season at Lincoln Financial Field on Sunday, October 5, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Eagles as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Broncos vs. Eagles predictions page.

Denver vs. Philadelphia early predictions

Leveraging trusted machine learning and analysis, we have simulated the Broncos vs. Eagles game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Broncos 36%, Eagles 64%
• Predicted final score: Broncos 20-24 Eagles
• Spread: Broncos (+4.5) 54%, Eagles (-4.5) 46%
• Total points (45.5): Over 50%, Under 50%

As of September 28, 2025, these Broncos-Eagles calculations and predictions reflect the latest data and insights available.

Broncos vs. Eagles Week 5 details

The NFL Week 5 action between the Eagles and Broncos at Lincoln Financial Field is scheduled for October 5, 2025.

• Who: Denver Broncos vs. Philadelphia Eagles
• Date: Sunday, October 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lincoln Financial Field

Broncos vs. Eagles opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Broncos +4.5 (-110), Eagles -4.5 (-110)
• Moneyline: Broncos +170, Eagles -205
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Eagles, with a 64% win probability, will likely beat the Broncos in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Broncos vs. Eagles game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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