Broncos vs. Chargers prediction: Chargers favored to win in NFL Week 3, 2025

The Los Angeles Chargers and Denver Broncos will meet in Week 3 of the NFL season at SoFi Stadium on Sunday, starting at 4:05PM ET.

Based on the latest simulation results, Dimers' advanced NFL model predicts the Chargers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Broncos-Chargers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Chargers with a win probability of 59%, while the Broncos have 41%."

This gameday Broncos vs. Chargers betting preview builds on my Broncos vs. Chargers prediction that was posted earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Broncos vs. Chargers predictions page.

Broncos vs. Chargers Predictions

Since our Broncos-Chargers predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Broncos and Chargers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Chargers a 59% chance of defeating the Broncos in Week 3 of the NFL season. Our predicted final score has the Chargers winning 24-21.

According to our model, the bookmakers have got it right, and the Broncos and Chargers each have a 50% chance of covering the spread, while the 45.5-point over/under also has an equal 50-50 chance of hitting.

Broncos vs. Chargers odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Broncos	Chargers
Spread	+2.5 (+100)	-2.5 (-120)
Moneyline	+136	-155
Total	o45.5 (-110)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Broncos vs. Chargers picks and best bets

Our model's biggest edge in today's Broncos vs. Chargers matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Broncos vs. Chargers TD scorers

Who will score the first touchdown in Broncos vs. Chargers?

According to our model, Los Angeles' Omarion Hampton is most likely to score the first TD in Broncos vs. Chargers.

Our projections give Hampton an 11.1% chance of scoring the first TD at SoFi Stadium, while the Chargers running back is a 42.2% chance of reaching the end zone at any point in the game.

First touchdown scorer predictions

Denver Broncos

Player	First TD Probability
J.K. Dobbins (RB)	8.7%
Courtland Sutton (WR)	6.7%
Troy Franklin (WR)	4.7%

Los Angeles Chargers

Player	First TD Probability
Omarion Hampton (RB)	11.1%
Ladd McConkey (WR)	8.4%
Quentin Johnston (WR)	7.0%

Anytime touchdown scorer predictions

Denver Broncos

Player	Anytime TD Probability
J.K. Dobbins (RB)	41.6%
Courtland Sutton (WR)	34.1%
Troy Franklin (WR)	25.3%

Los Angeles Chargers

Player	Anytime TD Probability
Omarion Hampton (RB)	42.2%
Ladd McConkey (WR)	34.0%
Quentin Johnston (WR)	29.4%

Broncos vs Chargers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Broncos and Chargers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Broncos-Chargers page now to access every player prop projection.

Broncos vs. Chargers quarterbacks

Of the starting quarterbacks, the Broncos' Bo Nix is projected to throw for fewer yards than the Chargers' Justin Herbert.

Broncos rushing

J.K. Dobbins, Bo Nix and RJ Harvey are projected to be the leading rushers for the Broncos.

Player	Position
J.K. Dobbins	RB
Bo Nix	QB
RJ Harvey	RB

Chargers rushing

Omarion Hampton, Najee Harris and Justin Herbert are expected to lead the Chargers in rushing yards.

Player	Position
Omarion Hampton	RB
Najee Harris	RB
Justin Herbert	QB

Broncos receiving

Courtland Sutton, Troy Franklin, Marvin Mims, Adam Trautman and Pat Bryant are projected to top the receiving yards for the Broncos.

Player	Position
Courtland Sutton	WR
Troy Franklin	WR
Marvin Mims	WR
Adam Trautman	TE
Pat Bryant	WR

Chargers receiving

Ladd McConkey, Keenan Allen, Quentin Johnston, Tyler Conklin and Omarion Hampton are projected to lead the Chargers in receiving yards.

Player	Position
Ladd McConkey	WR
Keenan Allen	WR
Quentin Johnston	WR
Tyler Conklin	TE
Omarion Hampton	RB

Broncos vs. Chargers game-day updates and essential details

The NFL Week 3 game between the Chargers and Broncos at SoFi Stadium is scheduled to start at 4:05PM ET.

• Who: Denver Broncos vs. Los Angeles Chargers
• Date: Sunday, September 21, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: SoFi Stadium

Dimers' in-depth preview of this week's Broncos vs. Chargers matchup includes our prediction, picks and the latest betting odds.

Before making any Broncos vs. Chargers picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Chargers, with a 59% win probability, will likely beat the Broncos in Week 3 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Broncos vs. Chargers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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