Denver Broncos vs. Los Angeles Chargers early prediction: Expert picks for NFL Week 3, 2025

The Denver Broncos and Los Angeles Chargers will meet in Week 3 of the NFL season at SoFi Stadium on Sunday, September 21, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Broncos vs. Chargers predictions page.

Denver vs. LA Chargers early predictions

Leveraging trusted machine learning and analysis, we have simulated the Broncos vs. Chargers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Broncos 45%, Chargers 55%
• Predicted final score: Broncos 21-23 Chargers
• Spread: Broncos (+1.5) 50%, Chargers (-1.5) 50%
• Total points (44.5): Over 50%, Under 50%

As of September 14, 2025, these Broncos-Chargers figures and predictions reflect the latest data and insights available.

Broncos vs. Chargers Week 3 details

The NFL Week 3 matchup between the Chargers and Broncos at SoFi Stadium is scheduled for September 21, 2025.

• Who: Denver Broncos vs. Los Angeles Chargers
• Date: Sunday, September 21, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: SoFi Stadium

Broncos vs. Chargers opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Broncos +1.5 (-110), Chargers -1.5 (-110)
• Moneyline: Broncos +105, Chargers -125
• Total: Over/Under 44.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chargers, with a 55% win probability, will likely beat the Broncos in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Broncos vs. Chargers game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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