Denver Broncos vs. Indianapolis Colts updated prediction featuring J.K. Dobbins, Jonathan Taylor [Week 2, 2025]

Dimers' latest NFL predictions are live for Indianapolis Colts and Denver Broncos in Week 2, with our model giving the Broncos a 59% of winning against the Colts on Sunday.

This update builds on our early Colts-Broncos predictions, presenting updated win probabilities, score projections, and TD predictions for J.K. Dobbins, Jonathan Taylor, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Broncos vs. Colts page.

What's changed? Denver vs. Indianapolis updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Broncos vs. Colts matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Broncos 59%, Colts 41%
• Predicted Final Score: Broncos 22-20 Colts
• Spread: Broncos (-1.5) 58%, Colts (+1.5) 42%
• Total Points (42.5): Over 50%, Under 50%

As of September 11, 2025, these Broncos-Colts figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Broncos-Colts on Sunday:

Denver Broncos

• J.K. Dobbins: 47.7% probability
• Courtland Sutton: 33.1% probability
• RJ Harvey: 25.0% probability

Indianapolis Colts

• Jonathan Taylor: 55.7% probability
• Michael Pittman: 24.2% probability
• Tyler Warren: 23.5% probability

Broncos vs. Colts latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Broncos -1.5 (-110), Colts +1.5 (-105)
• Moneyline: Broncos -124, Colts +110
• Total: Over/Under 42.5 (-110/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Broncos vs. Colts Week 2 details

The NFL Week 2 game between the Colts and Broncos at Lucas Oil Stadium is scheduled for September 14, 2025.

• Who: Denver Broncos vs. Indianapolis Colts
• Date: Sunday, September 14, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lucas Oil Stadium

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Conclusion

We predict the Broncos, with a 59% win probability, will likely beat the Colts in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Broncos vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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