Broncos vs. Colts prediction: Why Denver is favored to win in NFL Week 2, 2025

The Indianapolis Colts will face the Denver Broncos in NFL Week 2 action at Lucas Oil Stadium on Sunday, commencing at 4:05PM ET.

Based on updated simulations, Dimers' proven NFL model projects the Broncos as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Broncos-Colts game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Broncos with a win probability of 59%, while the Colts have 41%."

This gameday Broncos vs. Colts betting preview builds on my Broncos vs. Colts prediction that was released earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Broncos vs. Colts predictions page.

Broncos vs. Colts Predictions

Since our Broncos-Colts predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Broncos and Colts 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Broncos a 59% chance of defeating the Colts in Week 2 of the NFL season. Our predicted final score has the Broncos winning 22-20.

According to our model, the Broncos (-1.5) have a 53% chance of covering the spread, while the over/under total of 43.5 points has a 54% chance of staying under.

Broncos vs. Colts odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Broncos	Colts
Spread	-1.5 (-112)	+1.5 (-108)
Moneyline	-125	+110
Total	o43.5 (-105)	u43.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Broncos vs. Colts picks and best bets

Our model's biggest edge in today's Broncos vs. Colts matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Broncos vs. Colts TD scorers

Who will score an anytime touchdown in Broncos vs. Colts?

According to our model, Indianapolis' Jonathan Taylor is most likely to score the first touchdown in Broncos vs. Colts.

Our projections give Taylor a 13.9% chance of getting in for six first at Lucas Oil Stadium, while the Colts running back is a 52.7% chance of registering an anytime touchdown.

First touchdown scorer predictions

Denver Broncos

Player	First TD Probability
J.K. Dobbins (RB)	10.5%
Courtland Sutton (WR)	7.9%
RJ Harvey (RB)	5.8%

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor (RB)	13.9%
Michael Pittman (WR)	5.2%
Daniel Jones (QB)	5.2%

Anytime touchdown scorer predictions

Denver Broncos

Player	Anytime TD Probability
J.K. Dobbins (RB)	42.0%
Courtland Sutton (WR)	33.7%
RJ Harvey (RB)	26.1%

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor (RB)	52.7%
Michael Pittman (WR)	24.5%
Daniel Jones (QB)	24.3%

Broncos vs Colts player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Broncos and Colts. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Broncos-Colts page now to access every player prop projection.

Broncos vs. Colts quarterbacks

Of the starting quarterbacks, the Broncos' Bo Nix is projected to throw for more yards than the Colts' Daniel Jones.

Broncos rushing

J.K. Dobbins, RJ Harvey and Bo Nix are projected to be the leading rushers for the Broncos.

Player	Position
J.K. Dobbins	RB
RJ Harvey	RB
Bo Nix	QB

Colts rushing

Jonathan Taylor, Daniel Jones and DJ Giddens are expected to lead the Colts in rushing yards.

Player	Position
Jonathan Taylor	RB
Daniel Jones	QB
DJ Giddens	RB

Broncos receiving

Courtland Sutton, Marvin Mims, Troy Franklin, Evan Engram and J.K. Dobbins are projected to top the receiving yards for the Broncos.

Player	Position
Courtland Sutton	WR
Marvin Mims	WR
Troy Franklin	WR
Evan Engram	TE
J.K. Dobbins	RB

Colts receiving

Michael Pittman, Tyler Warren, Josh Downs, Alec Pierce and Jonathan Taylor are projected to lead the Colts in receiving yards.

Player	Position
Michael Pittman	WR
Tyler Warren	TE
Josh Downs	WR
Alec Pierce	WR
Jonathan Taylor	RB

Broncos vs. Colts game-day updates and essential details

The NFL Week 2 matchup between the Colts and Broncos at Lucas Oil Stadium is scheduled to start at 4:05PM ET.

• Who: Denver Broncos vs. Indianapolis Colts
• Date: Sunday, September 14, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lucas Oil Stadium

Dimers' comprehensive preview of this week's Broncos vs. Colts matchup includes our prediction, picks and the latest betting odds.

Before making any Broncos vs. Colts picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Broncos, with a 59% win probability, will likely beat the Colts in Week 2 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Broncos vs. Colts insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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