Denver Broncos vs. Indianapolis Colts early prediction: Expert picks for NFL Week 2, 2025

The Denver Broncos and Indianapolis Colts will meet in Week 2 of the NFL season at Lucas Oil Stadium on Sunday, September 14, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Broncos as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Broncos vs. Colts predictions page.

Denver vs. Indianapolis early predictions

Leveraging trusted machine learning and analysis, we have simulated the Broncos vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Broncos 62%, Colts 38%
• Predicted final score: Broncos 23-20 Colts
• Spread: Broncos (-3.5) 50%, Colts (+3.5) 50%
• Total points (44.5): Over 50%, Under 50%

As of September 7, 2025, these Broncos-Colts numbers and predictions reflect the latest data and insights available.

Broncos vs. Colts Week 2 details

The NFL Week 2 game between the Colts and Broncos at Lucas Oil Stadium is scheduled for September 14, 2025.

• Who: Denver Broncos vs. Indianapolis Colts
• Date: Sunday, September 14, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lucas Oil Stadium

Broncos vs. Colts opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Broncos -3.5 (-110), Colts +3.5 (-110)
• Moneyline: Broncos -185, Colts +154
• Total: Over/Under 44.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Broncos, with a 62% win probability, will likely beat the Colts in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Broncos vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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