Dallas Cowboys vs. Philadelphia Eagles early prediction: Expert picks for NFL Week 1, 2025

The Dallas Cowboys and Philadelphia Eagles will meet in Week 1 of the NFL season at Lincoln Financial Field on Thursday, September 4, 2025, starting at 8:20PM ET.

Initial simulations from Dimers' trusted NFL model favor the Eagles as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cowboys vs. Eagles predictions page.

Dallas vs. Philadelphia early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cowboys vs. Eagles game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cowboys 27%, Eagles 73%
• Predicted final score: Cowboys 19-26 Eagles
• Spread: Cowboys (+7.5) 56%, Eagles (-7.5) 44%
• Total points (47.5): Over 46%, Under 54%

As of August 31, 2025, these Cowboys-Eagles numbers and predictions reflect the latest data and insights available.

Cowboys vs. Eagles Week 1 details

The NFL Week 1 matchup between the Eagles and Cowboys at Lincoln Financial Field is scheduled for September 4, 2025.

• Who: Dallas Cowboys vs. Philadelphia Eagles
• Date: Thursday, September 4, 2025
• Time: 8:20PM ET/5:20PM PT
• Venue: Lincoln Financial Field

Cowboys vs. Eagles opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Cowboys +7.5 (-108), Eagles -7.5 (-110)
• Moneyline: Cowboys +310, Eagles -375
• Total: Over/Under 47.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 1 betting promos and codes

Make the most of Dimers' Cowboys vs. Eagles predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $300 in Bonus Bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in Bonus Bets win or lose.

Conclusion

We predict the Eagles, with a 73% win probability, will likely beat the Cowboys in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cowboys vs. Eagles game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.