UConn vs. Syracuse prediction: Syracuse favored to win in college football Week 2, 2025

Syracuse will square off with Connecticut in Week 2 college football action at JMA Wireless Dome on Saturday, starting at 12:00PM ET.

Based on updated simulation results, Dimers' proven college football model projects Syracuse as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive UConn vs. Syracuse predictions page.

UConn vs. Syracuse prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the result of UConn vs. Syracuse 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Syracuse a 64% chance of beating Connecticut. Our predicted final score has Syracuse winning 32-25.

According to our model, Connecticut (+7.5) has a 55% chance of covering the spread, while the over/under total of 57.5 points has an equal 50-50 chance of hitting.

UConn vs. Syracuse odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	UConn	Syracuse
Spread	+7.5 (-115)	-7.5 (-105)
Moneyline	+235	-275
Total	o57.5 (-105)	u57.5 (-110)

All odds are correct at the time of publication and are subject to change.

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UConn vs. Syracuse picks and best bets

Our model's biggest edge in today's UConn vs. Syracuse matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

UConn vs. Syracuse game-day updates and essential details

Saturday's college football game between Syracuse and UConn at JMA Wireless Dome is scheduled to begin at 12:00PM ET.

• Who: Connecticut vs. Syracuse
• Date: Saturday, September 6, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: JMA Wireless Dome

Dimers.com's comprehensive preview of Saturday's UConn vs. Syracuse matchup includes our prediction, picks and the latest betting odds.

Before making any UConn vs. Syracuse picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Syracuse, with a 64% win probability, will likely beat Connecticut on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Connecticut vs. Syracuse insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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