UConn vs. Buffalo prediction: Close contest projected after new data released for in college football Week 5, 2025

Buffalo and Connecticut will clash in Week 5 college football action at UB Stadium on Saturday, with kickoff at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model projects an equal chance for both the Buffalo and Connecticut to win today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive UConn vs. Buffalo predictions page.

UConn vs. Buffalo prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of UConn vs. Buffalo 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently can't split the two teams, giving both Connecticut and Buffalo a 50% chance of winning the game. Our predicted score is Connecticut 26-26 Buffalo.

According to our model, Buffalo (+3) has a 58% chance of covering the spread, while the 50.5-point over/under has a 54% chance of staying under.

While there is no way for a College Football game to end in a tie, our prediction of 26-26 is based on each team's average score in the above-mentioned simulations of Connecticut vs. Buffalo.

UConn vs. Buffalo odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	UConn	Buffalo
Spread	-3 (-110)	+3 (-110)
Moneyline	-132	+130
Total	o50.5 (-115)	u50.5 (-105)

All odds are correct at the time of publication and are subject to change.

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UConn vs. Buffalo picks and best bets

Our model's biggest edge in today's UConn vs. Buffalo matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

UConn vs. Buffalo game-day updates and essential details

Saturday's college football action between Buffalo and UConn at UB Stadium is scheduled to start at 3:30PM ET.

• Who: Connecticut vs. Buffalo
• Date: Saturday, September 27, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: UB Stadium

Dimers' full preview of Saturday's UConn vs. Buffalo matchup includes our prediction, picks and the latest betting odds.

Before making any UConn vs. Buffalo picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between Connecticut and Buffalo on Saturday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Connecticut vs. Buffalo insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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