Commanders vs. 49ers Week 16 Prediction and Odds - Dec 24, 2022

The San Francisco 49ers take on the Washington Commanders in NFL Week 16 action at Levi's Stadium on Saturday, beginning at 4:05PM ET.

Dimers' best betting picks for Commanders vs. 49ers, plus game predictions, betting odds and projected player stats, are detailed in this article.

Who will win Commanders vs. 49ers?

Based on high-tech machine learning and data, Dimers.com has simulated Saturday's Commanders-49ers NFL matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the 49ers a 79% chance of beating the Commanders in Week 16 of the NFL season.

More: Commanders vs. 49ers Simulated 10K Times

Commanders vs. 49ers Current Odds

• Spread: 49ers -6 (-105), Commanders +6 (-105)
• Moneyline: 49ers -275, Commanders +250
• Total: Over/Under 37 (-107/-107)

Point Spread, Moneyline and Over/Under

The 49ers are currently -6 favorites versus the Commanders, with -105 at Caesars Sportsbook the best odds currently available.

For the underdog Commanders (+6) to cover the spread, DraftKings Sportsbook has the best odds currently on the market at -105.

PointsBet currently has the best moneyline odds for the 49ers at -275. That means you can risk $275 to win $100, for a total payout of $375, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Commanders at +250, where you can bet $100 to profit $250, earning a total payout of $350, if they win.

The Over/Under for total points scored sits at 37 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (-6) are a 61% chance of covering the spread, while the 37-point Over/Under is a 55% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for Commanders vs. 49ers

• Spread: 49ers -6 @ -105 via Caesars Sportsbook (61% probability) 🔥
• Moneyline: 49ers @ -275 via PointsBet (79% probability) 🔥
• Total: Over 37 @ -107 via PointsBet (55% probability)

If you see a 🔥, that means it's one of our best bets of the day across any sport.

Our best bets are based on world-class simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

Commanders vs. 49ers Prediction

Dimers.com's predicted final score for Washington vs. San Francisco at Levi's Stadium in Week 16 has the 49ers winning 23-16.

Click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's Commanders-49ers matchup in Week 16, including pregame predictions, best betting picks, and live win probabilities.

Commanders vs. 49ers Player Props

Who will score the first touchdown in Commanders vs. 49ers? The latest data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Commanders and 49ers, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you select the best prop bets for Saturday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first touchdown in Commanders vs. 49ers.

DimersBOT gives McCaffrey a 17.7% chance of getting in for six first at Levi's Stadium, while the 49ers RB is a 57.8% chance of scoring an anytime touchdown.

Scroll down for the complete list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Washington Commanders

• Brian Robinson: 9.4% probability
• Antonio Gibson: 8.1% probability
• Terry McLaurin: 7.8% probability
• Curtis Samuel: 4.5% probability
• Jahan Dotson: 4.5% probability

San Francisco 49ers

• Christian McCaffrey: 17.7% probability
• George Kittle: 14.0% probability
• Brandon Aiyuk: 7.4% probability
• Jauan Jennings: 4.4% probability
• Jordan Mason: 3.1% probability

Anytime Touchdown Scorer Probabilities

Washington Commanders

• Brian Robinson: 35.5% probability
• Antonio Gibson: 30.7% probability
• Terry McLaurin: 28.9% probability
• Curtis Samuel: 18.7% probability
• Jahan Dotson: 18.0% probability

San Francisco 49ers

• Christian McCaffrey: 57.8% probability
• George Kittle: 49.4% probability
• Brandon Aiyuk: 28.7% probability
• Jauan Jennings: 19.3% probability
• Jordan Mason: 13.2% probability

Commanders-49ers Projected Player Stats

Of the starting quarterbacks, the Commanders' Taylor Heinicke is projected for 202 passing yards. The 49ers' Brock Purdy is expected to throw for just 174 yards.

Commanders Starting QB

• Taylor Heinicke: 202 projected yards

49ers Starting QB

• Brock Purdy: 174 projected yards

Commanders Rushing

• Brian Robinson: 58 projected yards
• Antonio Gibson: 29 projected yards
• Taylor Heinicke: 20 projected yards

49ers Rushing

• Christian McCaffrey: 77 projected yards
• Jordan Mason: 18 projected yards
• Brock Purdy: 14 projected yards

Commanders Receiving

• Terry McLaurin: 69 projected yards
• Jahan Dotson: 35 projected yards
• Curtis Samuel: 29 projected yards
• Logan Thomas: 24 projected yards
• Antonio Gibson: 24 projected yards

49ers Receiving

• Brandon Aiyuk: 57 projected yards
• George Kittle: 44 projected yards
• Christian McCaffrey: 44 projected yards
• Jauan Jennings: 25 projected yards
• Kyle Juszczyk: 12 projected yards

Don't forget, DimersBOT updates often, so keep checking this page for the latest betting insights before Commanders vs. 49ers on Saturday December 24, 2022.

Commanders vs. 49ers 2022

The NFL Week 16 matchup between the 49ers and Commanders at Levi's Stadium is scheduled to begin at 4:05PM ET.

• Who: Washington Commanders vs. San Francisco 49ers
• Date: Saturday December 24, 2022
• Time: 4:05PM ET / 1:05PM PT
• Venue: Levi's Stadium

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What other NFL games are on today?

Now you've got the 411 on Commanders vs. 49ers, get the latest betting coverage for all upcoming NFL games in Dimers' NFL Bet Hub. There you can find probabilities and odds, plus our best bets for every single NFL matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!