Columbia vs. Lafayette prediction: Lafayette favored to win in college football Week 4, 2025

Lafayette and Columbia will clash in Week 4 college football action at Fisher Stadium on Friday, with kickoff at 6:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts Lafayette as the most likely winner of today's game.

For a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Columbia vs. Lafayette predictions page.

Columbia vs. Lafayette prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Columbia vs. Lafayette 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Lafayette a 63% chance of beating Columbia. Our predicted final score has Lafayette winning 29-24.

According to our model, Lafayette (-3) has a 58% chance of covering the spread, while the over/under total of 54.5 points has a 52% chance of staying under.

Columbia vs. Lafayette odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Columbia	Lafayette
Spread	+3 (+100)	-3 (-115)
Moneyline	+136	-150
Total	o54.5 (-105)	u54.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Columbia vs. Lafayette picks and best bets

Our model's biggest edge in today's Columbia vs. Lafayette matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Columbia vs. Lafayette game-day updates and essential details

Friday's college football matchup between Lafayette and Columbia at Fisher Stadium is scheduled to begin at 6:00PM ET.

• Who: Columbia vs. Lafayette
• Date: Friday, September 19, 2025
• Time: 6:00PM ET/3:00PM PT
• Venue: Fisher Stadium

Dimers' in-depth preview of Friday's Columbia vs. Lafayette matchup includes our prediction, picks and the latest betting odds.

Before making any Columbia vs. Lafayette picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Lafayette, with a 63% win probability, will likely beat Columbia on Friday.

AI and automation have enhanced this article to quickly deliver accurate Columbia vs. Lafayette insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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