Colts vs. Cardinals Predictions and Odds - Dec 25, 2021

NFL Week 16 action continues on Christmas Day at 8:15PM EST as the Indianapolis Colts square off with the Arizona Cardinals at State Farm Stadium.

Dimers' best betting picks for Colts vs. Cardinals, plus game predictions, best odds and player props, are detailed in this article.

Who will win Colts vs. Cardinals?

Using state-of-the-art computer power and data, Dimers.com has simulated Saturday's Colts-Cardinals NFL matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Cardinals a 60% chance of defeating the Colts.

MORE: Colts vs. Cardinals Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

The Cardinals are -3 favorites versus the Colts, with -110 at BetMGM the best odds available.

For the underdog Colts (+3) to cover the spread, FanDuel Sportsbook has the best odds on offer at -104.

BetMGM has the best moneyline odds for the Cardinals at -159. That means you can risk $159 to win $100, for a total payout of $259, if they get the W.

Meanwhile, PointsBet has the best moneyline odds for the Colts at +150, where you can bet $100 to profit $150, earning a total payout of $250, if they win.

The Over/Under is set at 47.5 with PointsBet, which has the best odds for the Over at -110, while FanDuel Sportsbook has the best odds for the Under at -105.

As always, check out all the sportsbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the bookies have got it right and both the Colts and Cardinals are a 50% chance of covering the spread, while the 47.5-point Over/Under is a 51% chance of going Over.

MORE: Super Bowl 2022 Probabilities and Odds

Best Bets for Colts vs. Cardinals

• Spread: Colts +3 at -104 with FanDuel Sportsbook (50% probability)
• Moneyline: Colts Win at +150 with PointsBet
• Over/Under: Over 47.5 at -110 with PointsBet (51% probability)

While the Cardinals are more likely to win the game, according to DimersBOT, betting on the Colts moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds.

Taking advantage of the edges published here at Dimers.com is crucial to being profitable in the long run.

Colts vs. Cardinals Score Prediction

Dimers.com's predicted final score for Indianapolis vs. Arizona at State Farm Stadium this Saturday has the Cardinals winning 25-22.

Use our widget below to see the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Colts-Cardinals matchup, including pre-game predictions, top betting picks, and live win probabilities.

Colts vs. Cardinals Player Props

Who will score the first touchdown in Colts vs. Cardinals? The data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Colts and Cardinals, as well as projected player stats.

And you know what, we provide this information to you for FREE to help you select the best prop picks for Saturday's game.

According to DimersBOT, Indianapolis' Jonathan Taylor is most likely to score the first TD in Colts vs. Cardinals.

DimersBOT gives Taylor a 17.8% chance of scoring the first TD at State Farm Stadium, while the Colts RB is a 63.9% chance of scoring an anytime touchdown.

First Touchdown Scorer Probabilities

Indianapolis Colts

• Jonathan Taylor: 17.8% probability
• Michael Pittman: 7.1% probability
• Zach Pascal: 4.3% probability
• T.Y. Hilton: 4.0% probability
• Nyheim Hines: 3.8% probability

Arizona Cardinals

• Chase Edmonds: 11.8% probability
• Christian Kirk: 8.0% probability
• Kyler Murray: 7.4% probability
• A.J. Green: 7.2% probability
• Zach Ertz: 6.6% probability

Anytime Touchdown Scorer Probabilities

Indianapolis Colts

• Jonathan Taylor: 63.9% probability
• Michael Pittman: 35.4% probability
• Zach Pascal: 22.1% probability
• Nyheim Hines: 19.8% probability
• T.Y. Hilton: 19.3% probability

Arizona Cardinals

• Chase Edmonds: 48.1% probability
• Christian Kirk: 39.0% probability
• A.J. Green: 33.6% probability
• Kyler Murray: 33.6% probability
• Zach Ertz: 30.6% probability

Projected Box Score

Of the starting quarterbacks, the Colts' Carson Wentz is projected for 230 passing yards and 1.3 passing touchdowns. The Cardinals' Kyler Murray is expected to throw for 247 yards and 1.9 TDs.

Colts Starting QB

• Carson Wentz: 230 Passing Yards, 1.3 Passing TDs

Cardinals Starting QB

• Kyler Murray: 247 Passing Yards, 1.9 Passing TDs

Colts Rushing

• Jonathan Taylor: 103 Rushing Yards, 0.9 TDs
• Carson Wentz: 16 Rushing Yards, 0.1 TDs
• Nyheim Hines: 13 Rushing Yards, 0.1 TDs

Cardinals Rushing

• Chase Edmonds: 61 Rushing Yards, 0.4 TDs
• Kyler Murray: 35 Rushing Yards, 0.4 TDs
• Jonathan Ward: 13 Rushing Yards, 0.1 TDs

Colts Receiving

• Michael Pittman: 70 Receiving Yards, 0.4 TDs
• Zach Pascal: 35 Receiving Yards, 0.2 TDs
• T.Y. Hilton: 34 Receiving Yards, 0.2 TDs
• Jack Doyle: 21 Receiving Yards, 0.2 TDs
• Nyheim Hines: 20 Receiving Yards, 0.1 TDs

Cardinals Receiving

• Christian Kirk: 61 Receiving Yards, 0.4 TDs
• Zach Ertz: 49 Receiving Yards, 0.3 TDs
• A.J. Green: 46 Receiving Yards, 0.4 TDs
• Antoine Wesley: 32 Receiving Yards, 0.3 TDs
• Chase Edmonds: 31 Receiving Yards, 0.2 TDs

Remember, DimersBOT updates regularly, so keep checking this page for the latest betting insights before Colts vs. Cardinals on Saturday December 25, 2021.

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Colts vs. Cardinals 2021 Game Info

When do the Cardinals play the Colts?

• Date: Saturday December 25, 2021
• Time: 8:15PM EST / 5:15PM PST
• Venue: State Farm Stadium

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