Colts vs. Bills Predictions and Odds - Nov 21, 2021

The Buffalo Bills and Indianapolis Colts lock horns in Week 11 of the NFL season at Highmark Stadium on Sunday, with kickoff at 1:00 PM EST.

Dimers' best betting picks for Colts vs. Bills, as well as our score prediction and best odds, are detailed in this article.

Who will win Colts vs. Bills?

Using high-tech machine learning and data, Dimers.com has simulated Sunday's Colts-Bills matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Bills a 74% chance of winning against the Colts.

MORE: Full betting guide for Colts vs. Bills

Colts vs. Bills Point Spread, Moneyline and Over/Under

The Bills are -7 favorites at home to the Colts, with -105 at PointsBet the best odds available.

For the underdog Colts (+7) to cover the spread, BetMGM has the best odds on offer at -110.

FanDuel Sportsbook has the best moneyline odds for the Bills at -295. That means you can risk $295 to win $100, for a total payout of $395, if they get the W.

Meanwhile, BetMGM has the best moneyline odds for the Colts at +250, where you can bet $100 to profit $250, earning a total payout of $350, if they win.

The Over/Under sits at 49 with Caesars Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the bookmakers have got it right and both the Colts and Bills are a 50% chance of covering the spread, while the 49-point Over/Under is a 51% chance of going Over.

MORE: Best bets today for all major pro and college sports

Best Bets for Colts vs. Bills

• Spread: Bills -7 at -105 with PointsBet (50% probability)
• Moneyline: Bills Win at -295 with FanDuel Sportsbook (74% probability)
• Over/Under: Over 49 at -110 with Caesars Sportsbook (51% probability)

Colts vs. Bills Score Prediction

Dimers.com's predicted final score for Indianapolis vs. Buffalo at Highmark Stadium this Sunday has the Bills winning 28-21.

Dimers has full betting coverage of this week's Colts-Bills matchup, including pre-game predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates often, so keep checking this page for the latest ahead of Colts vs. Bills on Sunday November 21, 2021.

Colts vs. Bills 2021 Game Info

When do the Bills play the Colts?

• Date: Sunday November 21, 2021
• Time: 1:00 PM EST / 10:00 AM PST
• Venue: Highmark Stadium

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