Rockies vs. Mariners prediction: Seattle favored to win Wednesday's MLB matchup [9/24/2025]

The Seattle Mariners will face the Colorado Rockies in MLB action at T-Mobile Park on Wednesday, commencing at 9:40PM ET.

Luis Castillo (10-8, 3.64 ERA) will be on the bump for the Mariners, pitting him against Tanner Gordon (6-7, 6.00 ERA) for the Rockies.

Based on the latest simulations, Dimers' proven MLB model predicts the Mariners as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Rockies-Mariners game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 72%, with the Rockies at 28%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Rockies vs. Mariners predictions page.

Mariners vs. Rockies prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Rockies and Mariners 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Mariners a 72% chance of beating the Rockies.

According to our model, the Mariners (-1.5) have a 55% chance of covering the run line, while the over/under total of 7.5 runs has a 59% chance of going over.

Rockies vs. Mariners odds [9/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Rockies	Mariners
Run Line	+1.5 (+115)	-1.5 (-135)
Moneyline	+249	-300
Total	o7.5 (-102)	u7.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Rockies vs. Mariners picks and best bets

Our model's strongest edge in today's Rockies vs. Mariners matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Rockies vs. Mariners game-day updates and essential details

Wednesday's MLB action between the Mariners and Rockies at T-Mobile Park is scheduled to begin at 9:40PM ET.

• Who: Colorado Rockies vs. Seattle Mariners
• Date: Wednesday, September 24, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: T-Mobile Park

Dimers' in-depth preview of Wednesday's Rockies vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Rockies vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mariners, with a 72% win probability, will likely beat the Rockies on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Rockies vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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