Rockies vs. Giants prediction: San Francisco favored to win Friday's MLB matchup [9/26/2025]

The San Francisco Giants will face the Colorado Rockies in MLB action at Oracle Park on Friday, beginning at 10:15PM ET.

Trevor McDonald (0-0, 3.38 ERA) will get the ball for the Giants, while the Rockies have opted for Germán Márquez (3-15, 6.49 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Giants as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Rockies vs. Giants predictions page.

Giants vs. Rockies prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Friday's MLB game between the Rockies and Giants 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Giants a 65% chance of beating the Rockies.

According to our model, the Rockies (+1.5) have a 53% chance of covering the run line, while the 8.5-run over/under has a 56% chance of going over.

Rockies vs. Giants odds [9/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rockies	Giants
Run Line	+1.5 (-104)	-1.5 (-111)
Moneyline	+200	-240
Total	o8.5 (-105)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Rockies vs. Giants picks and best bets

Our model's strongest edge in today's Rockies vs. Giants matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Rockies vs. Giants game-day updates and essential details

Friday's MLB action between the Giants and Rockies at Oracle Park is scheduled to begin at 10:15PM ET.

• Who: Colorado Rockies vs. San Francisco Giants
• Date: Friday, September 26, 2025
• Time: 10:15PM ET/7:15PM PT
• Venue: Oracle Park

Dimers' in-depth preview of Friday's Rockies vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Rockies vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Giants, with a 65% win probability, will likely beat the Rockies on Friday.

AI and automation have enhanced this article to quickly deliver accurate Rockies vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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