Rockies vs. Padres prediction: San Diego favored to win Thursday's MLB matchup [9/11/2025]

The San Diego Padres and Colorado Rockies will lock horns in MLB action at PETCO Park on Thursday, starting at 9:40PM ET.

The Padres will send Randy Vásquez (4-6, 3.91 ERA) to the mound, while the Rockies have opted for McCade Brown (0-3, 12.54 ERA).

Based on the latest simulation results, Dimers' advanced MLB model projects the Padres as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Rockies vs. Padres predictions page.

Padres vs. Rockies prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Thursday's MLB matchup between the Rockies and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 67% chance of defeating the Rockies.

According to our model, the Rockies (+1.5) have a 51% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Rockies vs. Padres odds [9/11/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Rockies	Padres
Run Line	+1.5 (+109)	-1.5 (-125)
Moneyline	+220	-270
Total	o8.5 (-110)	u8.5 (-103)

All odds are correct at the time of publication and are subject to change.

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Rockies vs. Padres picks and best bets

Our model's biggest edge in today's Rockies vs. Padres matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Rockies vs. Padres game-day updates and essential details

Thursday's MLB action between the Padres and Rockies at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Colorado Rockies vs. San Diego Padres
• Date: Thursday, September 11, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers' full preview of Thursday's Rockies vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Rockies vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 67% win probability, will likely beat the Rockies on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Rockies vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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