Rockies vs. Padres prediction: San Diego favored to win Friday's MLB matchup [9/12/2025]

The San Diego Padres will face the Colorado Rockies in MLB action at PETCO Park on Friday, commencing at 9:40PM ET.

JP Sears (8-10, 5.01 ERA) will get the ball for the Padres, while the Rockies are going with Tanner Gordon (5-6, 6.60 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Padres as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Rockies vs. Padres predictions page.

Padres vs. Rockies prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB matchup between the Rockies and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Padres a 68% chance of defeating the Rockies.

According to our model, the Padres (-1.5) have a 51% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of going over.

Rockies vs. Padres odds [9/12/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Rockies	Padres
Run Line	+1.5 (+114)	-1.5 (-130)
Moneyline	+225	-270
Total	o8.5 (-110)	u8.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Rockies vs. Padres picks and best bets

Our model's biggest edge in today's Rockies vs. Padres matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Rockies vs. Padres game-day updates and essential details

Friday's MLB matchup between the Padres and Rockies at PETCO Park is scheduled to start at 9:40PM ET.

• Who: Colorado Rockies vs. San Diego Padres
• Date: Friday, September 12, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers' comprehensive preview of Friday's Rockies vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Rockies vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 68% win probability, will likely beat the Rockies on Friday.

AI and automation have enhanced this article to quickly deliver accurate Rockies vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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